Una nueva rábita en la playa de Guardamar del Segura: la rábita de El Moncayo

Se publican las noticias que ha arrojado la excavación en 2004 de unos muros situados en la denominada playa de El Moncayo. Los hallazgos se sitúan a unos 3 kilómetros al Sur del casco urbano de Guardamar del Segura; a unos 135 m. en dirección Norte está la Torre del Descargador (torre almenara de los siglos IV/X y V/XI), a unos 3,5 kilómetros se localiza El Castillo de Guardamar (de los siglos VIII a.C. al XIX) y, un poco más al Norte, a unos 4 kilómetros, en las proximidades de la desembocadura del Segura, los oratorios o rábitas de las dunas de Guardamar. Se dan a conocer los restos arquitectónicos y cerámicos aparecidos en la excavación del 2004 que se interpretan como de restos del recinto de una rábita o mezquitilla (cuando se excave más se verá si está aislada o hay más edificios similares), se presentan unos apuntes al hilo de la orientación de la rábita de El Moncayo y un estudio de la moneda andalusí hallada en la excavación de El Moncayo (datables entre en 429/1037-8 y 433/1041-2).Conclussions of the archeological excavation held in 2004 of some walls that appeared in the beach of El Moncayo (Guardamar del Segura, Alicante, Spain). This excavaion is located 3 kilometers at the south of the town of Guardamar del Segura; at 135 m. to the North direction is located the Tower del Descargador (vigilance tower 4-5 H./10-11 B.C. centuries), is located about 3.5 km of the castle of Guardamar (B.C. 8-19th cent.) and, about 4 miles further to the North -in the vicinity of the mouth of the Segura River-, there are the oratories or rábitas of the Guardamar dunes. We present the architectural and ceramic rests unveiled in the excavation of 2004 which are interpreted as remnants of a rabita or little mosque (when you dig more we will know if it is isolated or if there are more similar buildings). Also we present some notes over the orientation of the rabita's qibla of El Moncayo and we study of the Andalusian coin found in the excavations (datable between 429/1037-8 and 433/1041-2)

Phoenician colonization in the Iberian Peninsula: Cabezo Pequeño del Estaño (Guardamar del Segura, Alicante)

Este trabajo da a conocer los primeros resultados de la investigación de los autores en el enclave fenicio del Cabezo Pequeño del Estaño de Guardamar (Alicante). Dichos trabajos, consistentes en la revisión de los materiales exhumados en los años noventa y en el estudio arquitectónico con motivo de unas recientes tareas de consolidación, ayudan a definir más claramente el primer impacto de los agentes comerciales orientales en la costa levantina de la Península Ibérica y a comprender el desarrollo urbano del área del Bajo Segura que arrancó en época arcaica (siglos VIII-VII a.C.). El análisis de fotografías antiguas, anteriores a la destrucción parcial del enclave, ha permitido reconstruir su dimensión original (superior a una hectárea) y buena parte de su lienzo amurallado. Estos datos permiten considerar, además, el carácter urbano del yacimiento, anteriormente publicado como un pequeño fortín. En paralelo, los materiales arqueológicos procedentes de su última ocupación, fechados a finales del siglo VIII a.C., nos llevan a considerar que se trató del primer enclave colonial del Bajo Segura, abandonado en esas fechas por una población que se trasladó a un enclave de mayor tamaño y ubicado en mar abierto, conocido por el topónimo moderno de La Fonteta.In this paper the results of recent archaeological research in the settlement of Cabezo Pequeño del Estaño (Guardamar, Alicante) are presented. The research consists of the study of the materials excavated in the 1990s and an architectural analysis during recent restoration works. This new research allows us to better understand the first evidence of Phoenician colonization on the Alicante Coast as well as the settlement pattern in the area of the mouth of Segura River during the Early Iron Age. The analysis of old pictures, made before the partial destruction of the site, has allowed to reconstruct its original dimensions (over one hectare) and a large part of its walls. New data allow us to observe the urban features of the site, which was previously published as a small fort. In parallel, the archaeological materials from its last occupation, dated to the end of the eighth century BC, make us think that it was the first Phoenician site in the Segura mouth. It was abandoned at that time and the population moved to a larger site, located by the open sea and known by the modern name of La Fonteta.Investigación realizada bajo los auspicios del Excmo. Ayuntamiento de Guardamar del Segura y enmarcada en el Proyecto RYC2011-08222 “Transferencias culturales en el Mediterráneo Antiguo” del Ministerio de Economía y Competitividad

El Museo Arqueológico de Guardamar, MAG

El Museo Arqueológico de Guardamar, MAG, se emplaza en la Casa de Cultura. El MAG tiene su origen a finales de la década de los 80 del siglo pasado. Por estas fechas, con la democratización de la cultura, el Ayuntamiento de Guardamar comenzó a desarrollar un proyecto para la recuperación de su patrimonio cultural. No obstante, su reconocimiento por la Conselleria de Cultura se produjo en 1993. En el Museo, sometido en la actualidad a un proyecto de reforma de carácter interpretativo, se exponen una selección variada de materiales procedentes de los yacimientos arqueológicos que jalonan el término municipal. Destacan los materiales fenicios de La Fonteta, los ajuares funerarios de Cabezo Lucero y las terracotas ibéricas del castillo de Guardamar, así como un conjunto de ánforas y otros efectos navales de época romana. De la Edad Media, se reseña una selección de materiales procedentes del Ribat Califal de las Dunas y una interesante colección de cerámicas y otros objetos procedentes de la «vila murada» de Guardamar

Murallas fenicias de occidente. Una valoración conjunta de las defensas del Cerro del Castillo (Chiclana, Cádiz) y del Cabezo Pequeño del Estaño (Guardamar, Alicante)

En estas páginas vamos a realizar un estudio y valoración de conjunto de las fortificaciones de dos enclaves fenicios arcaicos localizados en dos espacios geográficos de máximo interés para el estudio de la presencia colonial en el ámbito hispano: el Cerro del Castillo de Chiclana de la Frontera (Cádiz) y el Cabezo Pequeño del Estaño de Guardamar del Segura (Alicante). Ambos ejemplos son, hasta el momento, los dos únicos conocidos en suelo español que presentan unas murallas de compartimentos, casernas y casamatas de tipología y modulación oriental. Este tipo de fortificación se generalizó en los ambientes costeros de sirio-palestina desde el Bronce Medio y, según se desprende de los datos que aquí se presentan, fue trasladado al extremo occidente a lo largo del siglo VIII a.C., en un momento en el que la empresa comercial fenicia necesitaba de una arquitectura flexible, casi inmediata y eficaz, tanto militarmente como para el almacenaje de productos.In these pages we will carry out a study and comprehensive assessment of the fortifications of two archaic Phoenician enclaves located in two geographical areas of maximum interest for the study of Colonial presence in Iberia: the Cerro del Castillo (Chiclana de la Frontera, Cadiz) and the Cabezo Pequeño del Estaño (Guardamar del Segura , Alicante). Both examples are, so far, the only known on occident presenting casemate-walls and Phoenician modulation. This type of fortification is developed in the coastal environments of Syrian-Palestinian from the 12th century B.C. and they were moved to the extreme West during the 8th century BC, at a time where the Phoenicians needed a flexible, almost immediate and very effective architecture, both militarily and for storage

Preliminary advance of Archaeoseismic evidences in a settlement Phoenician (8th b.C. Century), Guardamar de Segura (Alicante, Spain)

En este trabajo se presenta uno de los episodios sísmicos más antiguos registrados en una población de la Península Ibérica, al menos, que se tenga constancia hasta este momento. Más exactamente, en un poblado fortificado del siglo VIII a.C ubicado en las proximidades de Guardamar de Segura en Alicante (España). A continuación, se expone tanto el contexto arqueológico-histórico del yacimiento, como las evidencias del terremoto visibles aún en la muralla.This work supposes to expose one of the oldest seismic episodes recorded in a population of the Iberian Peninsula, at least that is known until this moment. More precisely, in a small Phoenician fortress from the 8th century BC in the vicinity of Guardamar de Segura in Alicante (Spain). Next, the archaeological-historical context of the site is exposed, as well as the evidences of the earthquake still visible in the wall

From Phoenician Astarte to the Iberian Mother-Goddess. Analysis of the archaeological documentation from the sanctuary of Castillo de Guardamar (Alicante)

Este artículo se concentra en las fases más antiguas del yacimiento ubicado en el cerro del Castillo de Guardamar del Segura (Alicante). Junto a la presentación de un lote de materiales arqueológicos en su mayoría inéditos o poco conocidos, se plantea la existencia de un santuario que pudo estar activo desde el siglo VIII a.C. A partir del análisis de los distintos hallazgos y de la iconografía de las terracotas existentes, se propone una advocación para este espacio sacro: la diosa Astarté fenicia, cuyo culto se pudo prolongar en este lugar a lo largo de prácticamente todo el primer milenio a.C.This article focuses on the earliest phases of the site located on the hill where the castle of Guardamar del Segura (Alicante) lies. Along with the presentation of several mostly unpublished or little-known archaeological materials, the existence of a sanctuary that could have been active since the 8th century BC is proposed. Based on the analysis of the different finds and the iconography of terracotta figurines, the dedication of this sacred space is proposed: Phoenician goddess Astarte, whose cult would have continued throughout practically the entire first millennium BC in this place.El trabajo se enmarca en el Proyecto LIMOS. Litoral y Montañas en transición. Arqueología del cambio social en las comarcas meridionales de la Comunidad Valenciana (Prometeo 2019/035) financiado por la Generalitat Valenciana

Analysis of the mutational landscape of classic Hodgkin lymphoma identifies disease heterogeneity and potential therapeutic targets

Defining the mutational landscape of classic Hodgkin lymphoma is still a major research goal. New targeted next-generation sequencing (NGS) techniques may identify pathogenic mechanisms and new therapeutic opportunities related to this disease. We describe the mutational profile of a series of 57 cHL cases, enriched in Hodgkin and Reed-Sternberg (HRS) cells. Overall, the results confirm the presence of strong genomic heterogeneity. However, several variants were consistently detected in genes related to relevant signaling pathways, such as GM-CSF/IL-3, CBP/EP300, JAK/STAT, NF-kappaB, and numerous variants of genes affecting the B-cell receptor (BCR) pathway, such as BTK, CARD11, BCL10, among others. This unexpectedly high prevalence of mutations affecting the BCR pathway suggests some requirement for active BCR signaling for cHL cell viability. Additionally, incubation of a panel of cHL cellular models with selective BTK inhibitors in vitro constrains cell proliferation and causes cell death. Our results indicate new pathogenic mechanisms and therapeutic opportunities in this disease

Genetic and phenotypic characterisation of HIV-associated aggressive B-cell non-Hodgkin lymphomas, which do not occur specifically in this population: diagnostic and prognostic implications

The frequency of aggressive subtypes of B-cell non-Hodgkin lymphoma (B-NHL), such as high-grade B-cell lymphomas (HGBL) with MYC and BCL2 and/or BCL6 rearrangement (HGBL-DH/TH) or Burkitt-like lymphoma (BL) with 11q aberration, is not well known in the HIV setting. We aimed to characterise HIV-associated aggressive B-NHL according to the 2017 WHO criteria, and to identify genotypic and phenotypic features with prognostic impact. Seventy-five HIV-associated aggressive B-NHL were studied by immunohistochemistry (CD10, BCL2, BCL6, MUM1, MYC, and CD30), EBV-encoded RNAs (EBERs), and fluorescence in situ hybridisation (FISH) to evaluate the status of the MYC, BCL2, and BCL6 genes and chromosome 11q. The 2017 WHO classification criteria and the Hans algorithm, for the cell-of-origin classification of diffuse large B-cell lymphomas (DLBCL), were applied. In DLBCL cases, the frequencies of MYC and BCL6 rearrangements (14.9 and 27.7%, respectively) were similar to those described in HIV-negative patients, but BCL2 rearrangements were infrequent (4.3%). MYC expression was identified in 23.4% of DLBCL cases, and coexpression of MYC and BCL2 in 13.0%, which was associated with a worse prognosis. As for BL cases, the expression of MUM1 (30.4%) conferred a worse prognosis. Finally, the prevalence of HGBL-DH/TH and BL-like with 11q aberration are reported in the HIV setting. The phenotypic and genotypic characteristics of HIV-associated aggressive B-NHL are similar to those of the general population, except for the low frequency of BCL2 rearrangements in DLBCL. MYC and BCL2 coexpression in DLBCL, and MUM-1 expression in BL, have a negative prognostic impact on HIV-infected individuals.Peer reviewe

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group